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📕 Improvements to the Practical Usability of the “Crystalline Sponge” Method for Organic Structure Determination


Tags: xray crystalline sponge news
Greyson W. Waldhart, Neal P. Mankad, and Bernard D. Santarsiero
Organic Letters ASAP, xxx-yyy (2016)
DOI:10.1021/acs.orglett.6b03119


Abstract

TOC graphic of this publication

A microwell droplet approach provided high-quality samples in ≥90% yield of the “crystalline sponge”, which was exhibited previously as a revolutionary organic structure determination method. The new protocol, from crystal growth to guest soaking, was conducted in 1–7 days (depending on the guest) and was robust toward user errors, marking improvements over existing protocols. Unit cell determination was used as a practical crystal screening metric. These advances improve the practicality of the crystalline sponge technique for characterizing unknown organic molecules.